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γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma.
Pont MJ, Hill T, Cole GO, Abbott JJ, Kelliher J, Salter AI, Hudecek M, Comstock ML, Rajan A, Patel BKR, Voutsinas JM, Wu Q, Liu L, Cowan AJ, Wood BL, Green DJ, Riddell SR. Pont MJ, et al. Among authors: abbott jj. Blood. 2019 Nov 7;134(19):1585-1597. doi: 10.1182/blood.2019000050. Blood. 2019. PMID: 31558469 Free PMC article.
GSI treatment of MM tumor-bearing NOD/SCID/gammac-/- mice increased BCMA expression on tumor cells, decreased sBCMA in peripheral blood, and improved antitumor efficacy of BCMA-targeted CAR T-cell therapy. Importantly, short-term GSI administration to MM patients markedly …
GSI treatment of MM tumor-bearing NOD/SCID/gammac-/- mice increased BCMA expression on tumor cells, decreased sBCMA in peripheral blood, and …
Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.
Abbott JJ, Howlett DR, Francis PT, Williams RJ. Abbott JJ, et al. Neurobiol Aging. 2008 Jul;29(7):992-1001. doi: 10.1016/j.neurobiolaging.2007.01.003. Epub 2007 Feb 9. Neurobiol Aging. 2008. PMID: 17292512
Abeta has been shown to be toxic to neurons and to inhibit long-term potentiation yet, the intracellular signalling pathways underlying these actions are unknown. ...
Abeta has been shown to be toxic to neurons and to inhibit long-term potentiation yet, the intracellular signalling pathways underlyi …
Adenocarcinoma of mammary-like glands of the vulva: Report of a case and review of the literature.
Abbott JJ, Ahmed I. Abbott JJ, et al. Am J Dermatopathol. 2006 Apr;28(2):127-33. doi: 10.1097/01.dad.0000171601.25315.2b. Am J Dermatopathol. 2006. PMID: 16625074 Review.
Use of aggressive surgical therapeutic regimens, particularly in the case of tumors localized to the skin, must be reassessed, especially given the likelihood of long-term morbidity with such regimens. In our patient, successful Mohs micrographic surgery suggests that alte …
Use of aggressive surgical therapeutic regimens, particularly in the case of tumors localized to the skin, must be reassessed, especially gi …