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γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma.
Blood. 2019 Nov 7;134(19):1585-1597. doi: 10.1182/blood.2019000050.
Blood. 2019.
PMID: 31558469
Free PMC article.
GSI treatment of MM tumor-bearing NOD/SCID/gammac-/- mice increased BCMA expression on tumor cells, decreased sBCMA in peripheral blood, and improved antitumor efficacy of BCMA-targeted CAR T-cell therapy. Importantly, short-term GSI administration to MM patients markedly …
GSI treatment of MM tumor-bearing NOD/SCID/gammac-/- mice increased BCMA expression on tumor cells, decreased sBCMA in peripheral blood, and …
Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.
Abbott JJ, Howlett DR, Francis PT, Williams RJ.
Abbott JJ, et al.
Neurobiol Aging. 2008 Jul;29(7):992-1001. doi: 10.1016/j.neurobiolaging.2007.01.003. Epub 2007 Feb 9.
Neurobiol Aging. 2008.
PMID: 17292512
Abeta has been shown to be toxic to neurons and to inhibit long-term potentiation yet, the intracellular signalling pathways underlying these actions are unknown. ...
Abeta has been shown to be toxic to neurons and to inhibit long-term potentiation yet, the intracellular signalling pathways underlyi …
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Adenocarcinoma of mammary-like glands of the vulva: Report of a case and review of the literature.
Abbott JJ, Ahmed I.
Abbott JJ, et al.
Am J Dermatopathol. 2006 Apr;28(2):127-33. doi: 10.1097/01.dad.0000171601.25315.2b.
Am J Dermatopathol. 2006.
PMID: 16625074
Review.
Use of aggressive surgical therapeutic regimens, particularly in the case of tumors localized to the skin, must be reassessed, especially given the likelihood of long-term morbidity with such regimens. In our patient, successful Mohs micrographic surgery suggests that alte …
Use of aggressive surgical therapeutic regimens, particularly in the case of tumors localized to the skin, must be reassessed, especially gi …
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