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Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.
Järvinen HJ, Renkonen-Sinisalo L, Aktán-Collán K, Peltomäki P, Aaltonen LA, Mecklin JP. Järvinen HJ, et al. Among authors: aaltonen la. J Clin Oncol. 2009 Oct 1;27(28):4793-7. doi: 10.1200/JCO.2009.23.7784. Epub 2009 Aug 31. J Clin Oncol. 2009. PMID: 19720893
PURPOSE: Colonoscopies with polypectomies and endometrial biopsies with transvaginal ultrasonography, repeated at 2- to 3-year intervals, are performed for prevention or early detection of cancer in patients with DNA mismatch repair gene mutation causing Lynch syndrome. The long- …
PURPOSE: Colonoscopies with polypectomies and endometrial biopsies with transvaginal ultrasonography, repeated at 2- to 3-year intervals, ar …
Aryl hydrocarbon receptor-interacting protein and acromegaly.
Aaltonen LA. Aaltonen LA. Horm Res. 2007;68 Suppl 5:127-31. doi: 10.1159/000110607. Epub 2007 Dec 10. Horm Res. 2007. PMID: 18174729
Of those individuals, 16% were positive for a mutation of the aryl hydrocarbon receptor-interacting protein (AIP) mutation. We proposed using the term pituitary adenoma predisposition (PAP) to describe a person with an AIP germline mutation. ...
Of those individuals, 16% were positive for a mutation of the aryl hydrocarbon receptor-interacting protein (AIP) mutation. We proposed usin …
EPHB4 and survival of colorectal cancer patients.
Davalos V, Dopeso H, Castaño J, Wilson AJ, Vilardell F, Romero-Gimenez J, Espín E, Armengol M, Capella G, Mariadason JM, Aaltonen LA, Schwartz S Jr, Arango D. Davalos V, et al. Among authors: aaltonen la. Cancer Res. 2006 Sep 15;66(18):8943-8. doi: 10.1158/0008-5472.CAN-05-4640. Cancer Res. 2006. PMID: 16982731
In addition, we provide mechanistic evidence showing that promoter methylation regulates EPHB4 transcription and functional evidence that EPHB4 can regulate the long-term clonogenic potential of colorectal tumor cells, revealing EPHB4 as a potential new tumor suppressor ge …
In addition, we provide mechanistic evidence showing that promoter methylation regulates EPHB4 transcription and functional evidence that EP …
Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis.
Laiho P, Kokko A, Vanharanta S, Salovaara R, Sammalkorpi H, Järvinen H, Mecklin JP, Karttunen TJ, Tuppurainen K, Davalos V, Schwartz S Jr, Arango D, Mäkinen MJ, Aaltonen LA. Laiho P, et al. Among authors: aaltonen la. Oncogene. 2007 Jan 11;26(2):312-20. doi: 10.1038/sj.onc.1209778. Epub 2006 Jul 3. Oncogene. 2007. PMID: 16819509
The study also provides a platform to understand the molecular basis of serrated CRC and in long term may contribute to the development of specific treatment options for this tumor type....
The study also provides a platform to understand the molecular basis of serrated CRC and in long term may contribute to the developme …