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Pharmacological activation of Nr4a rescues age-associated memory decline.
Chatterjee S, Walsh EN, Yan AL, Giese KP, Safe S, Abel T. Chatterjee S, et al. Neurobiol Aging. 2020 Jan;85:140-144. doi: 10.1016/j.neurobiolaging.2019.10.001. Epub 2019 Oct 14. Neurobiol Aging. 2020. PMID: 31732218 Free PMC article.
Previously, we have shown that Nr4a transcription can be activated by synthetic bisindole-derived compounds (C-DIM). C-DIM compounds enhance synaptic plasticity and long-term contextual fear memory in young healthy mice. In this study, we show that activation of Nr4a2 by 1 …
Previously, we have shown that Nr4a transcription can be activated by synthetic bisindole-derived compounds (C-DIM). C-DIM compounds enhance …
Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
Havekes R, Park AJ, Tolentino RE, Bruinenberg VM, Tudor JC, Lee Y, Hansen RT, Guercio LA, Linton E, Neves-Zaph SR, Meerlo P, Baillie GS, Houslay MD, Abel T. Havekes R, et al. J Neurosci. 2016 Aug 24;36(34):8936-46. doi: 10.1523/JNEUROSCI.0248-16.2016. J Neurosci. 2016. PMID: 27559174 Free PMC article.
However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in vivo Here, we show that increasing protein levels of the PDE4A5 isoform in mouse hippocampal excitatory neurons impairs a long-lasting form of hippocampal synaptic plasticity and att …
However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in vivo Here, we show that increasing protein …
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1.
Havekes R, Park AJ, Tudor JC, Luczak VG, Hansen RT, Ferri SL, Bruinenberg VM, Poplawski SG, Day JP, Aton SJ, Radwańska K, Meerlo P, Houslay MD, Baillie GS, Abel T. Havekes R, et al. Elife. 2016 Aug 23;5:e13424. doi: 10.7554/eLife.13424. Elife. 2016. PMID: 27549340 Free PMC article.
Suppression of cofilin function prevents spine loss, deficits in hippocampal synaptic plasticity, and impairments in long-term memory caused by sleep deprivation. The elevated cofilin activity is caused by cAMP-degrading phosphodiesterase-4A5 (PDE4A5), which hampers cAMP-P …
Suppression of cofilin function prevents spine loss, deficits in hippocampal synaptic plasticity, and impairments in long-term memory …
Statistical Learning with Time Series Dependence: An Application to Scoring Sleep in Mice.
McShane BB, Jensen ST, Pack AI, Wyner AJ. McShane BB, et al. J Am Stat Assoc. 2013 Jan 1;108(504):1147-1162. doi: 10.1080/01621459.2013.779838. J Am Stat Assoc. 2013. PMID: 24504359 Free PMC article.
We develop methodology which combines statistical learning methods with generalized Markov models, thereby enhancing the former to account for time series dependence. Our methodology can accommodate very general and very long-term time dependence structures in an easily es …
We develop methodology which combines statistical learning methods with generalized Markov models, thereby enhancing the former to account f …
Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory.
Prince TM, Wimmer M, Choi J, Havekes R, Aton S, Abel T. Prince TM, et al. Neurobiol Learn Mem. 2014 Mar;109:122-30. doi: 10.1016/j.nlm.2013.11.021. Epub 2013 Dec 28. Neurobiol Learn Mem. 2014. PMID: 24380868 Free PMC article.
To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sleep deprived following training in the hippocampus-dependent object place recognition task. ...Furthermore, a 3-h s …
To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was a …
Daily acclimation handling does not affect hippocampal long-term potentiation or cause chronic sleep deprivation in mice.
Vecsey CG, Wimmer ME, Havekes R, Park AJ, Perron IJ, Meerlo P, Abel T. Vecsey CG, et al. Sleep. 2013 Apr 1;36(4):601-7. doi: 10.5665/sleep.2556. Sleep. 2013. PMID: 23565007 Free PMC article.
DESIGN: Adult C57BL/6J mice were either handled daily for 6 days or were left undisturbed in their home cages. On the day after the 6(th) day of handling, long-term potentiation (LTP) was induced in hippocampal slices with spaced four-train stimulation, which we previously …
DESIGN: Adult C57BL/6J mice were either handled daily for 6 days or were left undisturbed in their home cages. On the day after the 6(th) da …
Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus.
Vecsey CG, Peixoto L, Choi JH, Wimmer M, Jaganath D, Hernandez PJ, Blackwell J, Meda K, Park AJ, Hannenhalli S, Abel T. Vecsey CG, et al. Physiol Genomics. 2012 Oct 17;44(20):981-91. doi: 10.1152/physiolgenomics.00084.2012. Epub 2012 Aug 28. Physiol Genomics. 2012. PMID: 22930738 Free PMC article.
Because protein synthesis and mTOR activation are required for long-term memory formation, our study improves our understanding of the molecular mechanisms underlying the memory impairments induced by sleep deprivation....
Because protein synthesis and mTOR activation are required for long-term memory formation, our study improves our understanding of th …
13 results