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PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation.
Ngo G, Hyatt S, Grimstead J, Jones R, Hendrickson E, Pepper C, Baird D. Ngo G, et al. Oncotarget. 2018 Dec 25;9(101):37549-37563. doi: 10.18632/oncotarget.26499. eCollection 2018 Dec 25. Oncotarget. 2018. PMID: 30680069 Free PMC article.
This is the first demonstration that a drug can selectively kill cells experiencing telomeric crisis. We propose that this type of drug, which we term 'crisolytic', has the potential to eliminate pre-cancerous lesions and tumours exhibiting short dysfunctional telomeres... …
This is the first demonstration that a drug can selectively kill cells experiencing telomeric crisis. We propose that this type of drug, whi …
Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis.
Garcia-Martin I, Janssen AB, Jones RE, Grimstead JW, Penketh RJA, Baird DM, John RM. Garcia-Martin I, et al. Placenta. 2017 Nov;59:61-68. doi: 10.1016/j.placenta.2017.09.007. Epub 2017 Sep 20. Placenta. 2017. PMID: 29108638 Free PMC article.
In this study, we applied Single Telomere Length Analysis (STELA) which provides high-resolution chromosome specific telomere length profiles to ask whether we could obtain more detailed information on the length of individual telomeres in the placenta. METHODS: Term place …
In this study, we applied Single Telomere Length Analysis (STELA) which provides high-resolution chromosome specific telomere length profile …
Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.
Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Pawlikowski JS, Norris KT, Criscione SW, Pchelintsev NA, Piscitello D, Stong N, Rai TS, McBryan T, Otte GL, Nixon C, Clark W, Riethman H, Wu H, Schotta G, Garcia BA, Neretti N, Baird DM, Berger SL, Adams PD. Nelson DM, et al. Genome Biol. 2016 Jul 25;17(1):158. doi: 10.1186/s13059-016-1017-x. Genome Biol. 2016. PMID: 27457071 Free PMC article.
Rather, we speculate that H4K20me3 plays a role in heterochromatinization and stabilization of the epigenome and genome of pre-malignant, oncogene-expressing senescent cells, thereby suppressing epigenetic and genetic instability and contributing to long-term senescence-me …
Rather, we speculate that H4K20me3 plays a role in heterochromatinization and stabilization of the epigenome and genome of pre-malignant, on …