Erythropoiesis after therapy with recombinant human erythropoietin: a dose-response study in anemic cancer surgery patients

Vox Sang. 1999;76(1):38-42.

Abstract

Background and objectives: Preoperative treatment with 600 U/kg of recombinant human erythropoietin (r-HuEPO) effectively increases erythropoiesis in cancer patients. The aim of this study was to evaluate the erythropoietic response after different doses of r-HuEPO in order to find the minimum effective dose.

Materials and methods: Twenty anemic sideropenic patients (hemoglobin </=110 g/l; serum iron <600 microg/l) with cancer of the gastrointestinal tract were randomly allocated to two groups: the first (n = 10) received 400 U/kg of r-Hu EPO divided in 4 doses (100 U/kg each, every 4 days); the second (n = 10) received 200 U/kg of r-HuEPO (50 U/kg each, every 4 days). Both groups were given intravenous iron gluconate (125 mg) every day for 15 days.

Results: After treatment, the serum iron level significantly rose in both groups. The production of new red blood cells was 176.3+/-90.8 ml in the 200 U/kg group and 268.4+/-79.4 ml in the 400 U/kg group (p = 0.036). The increase of hemoglobin was significantly higher in the 400 U/kg group (22.3+/-2.0 g/l) than in the 200 U/kg group (14.1+/-2.7 g/l) (p = 0.017).

Conclusion: The r-HuEPO dose of 400 U/kg appears significantly more effective than the 200 U/kg to stimulate erythropoiesis in anemic sideropenic cancer patients.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / surgery*
  • Aged
  • Anemia / drug therapy*
  • Colorectal Neoplasms / drug therapy
  • Colorectal Neoplasms / surgery*
  • Dose-Response Relationship, Drug
  • Erythropoiesis / drug effects*
  • Erythropoietin / therapeutic use*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Neoplasms / drug therapy
  • Pancreatic Neoplasms / surgery*
  • Preoperative Care
  • Prospective Studies
  • Recombinant Proteins
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / surgery*

Substances

  • Recombinant Proteins
  • Erythropoietin