Murine regional brain monoamine oxidase activity: time- and age-dependent response to inhibitors

Gerontology. 1984;30(2):87-93. doi: 10.1159/000212613.

Abstract

The inhibitory effect of procaine hydrochloride and Gerovital-H3 on monoamine oxidase (MAO) activity in the rat brain was studied at six time points during the 24-hour cycle. It was found that the percent inhibition is time dependent. Both drugs showed maximum inhibition when the MAO activity was at the lowest values during the 24-hour period. In addition to time dependence, these drugs are also age dependent because the MAO activity varies with age.

MeSH terms

  • Aging*
  • Analysis of Variance
  • Animals
  • Brain / enzymology*
  • Male
  • Monoamine Oxidase / metabolism*
  • Monoamine Oxidase Inhibitors / pharmacology*
  • Procaine / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Time Factors
  • Tissue Distribution

Substances

  • Monoamine Oxidase Inhibitors
  • Gerovital H3
  • Procaine
  • Monoamine Oxidase