Abstract
Seventeen cystic fibrosis patients aged 3.1 years to 19.8 years had 30 courses of intensive treatment for relapse of their pseudomonas chest infection. The combination of netilmicin and ticarcillin was compared with tobramycin and ticarcillin in an open study. A significant subjective and objective improvement occurred in all patients. Pseudomonas was cleared temporarily from the sputum in 11 out of the 30 courses of treatment (37%). There was no significant difference between the netilmicin and tobramycin groups, nor evidence of sustained renal or ototoxicity. Intensive therapy of pseudomonas chest infection in cystic fibrosis patients is described in detail.
Publication types
-
Clinical Trial
-
Comparative Study
-
Controlled Clinical Trial
MeSH terms
-
Adolescent
-
Adult
-
Child
-
Child, Preschool
-
Clinical Trials as Topic
-
Cystic Fibrosis / complications
-
Cystic Fibrosis / drug therapy*
-
Drug Combinations
-
Female
-
Gentamicins / therapeutic use*
-
Humans
-
Lung Volume Measurements
-
Male
-
Netilmicin / therapeutic use*
-
Penicillins / therapeutic use*
-
Pseudomonas Infections / drug therapy*
-
Pseudomonas Infections / etiology
-
Respiratory Tract Infections / drug therapy*
-
Respiratory Tract Infections / etiology
-
Sputum / microbiology
-
Ticarcillin / therapeutic use*
-
Tobramycin / therapeutic use*
Substances
-
Drug Combinations
-
Gentamicins
-
Penicillins
-
Netilmicin
-
Ticarcillin
-
Tobramycin