The concept of home care therapy for acute respiratory exacerbations in cystic fibrosis (CF) has been developed in a number of treatment centers during the last few years. Objective and prospective clinical observations have demonstrated that home care therapy is as effective as structured hospital treatments in improving pulmonary function and body weight in patients with CF. Moreover, the medical, social, and financial benefits of home care suggest that such an approach to the management should be developed further in order to improve the quality of life of patients with CF.