Abstract
Fifty cystic fibrosis (CF) patients, of whom 9 had multilobular cirrhosis, were observed regularly for a period of 3 years and various liver function tests, indicating cytolysis, cholestasis and cellular insufficiency were performed. Immunoglobulin and prothrombin were assayed. In 9 patients with cirrhosis, the tests were generally abnormal. Two distinct biochemical patterns of cirrhosis were distinguished, one clearly cholestatic and the other of a more cellular type. The distinction was made on the basis of the IgA : Transferrin ratio and of gamma-glutamyl-transpeptidase levels. In the non-cirrhotic patients, a temporary increase of cytolysis and cholestasis was observed in 50% of the cases.
MeSH terms
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Adolescent
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Adult
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Alanine Transaminase / blood
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Alkaline Phosphatase / blood
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Child
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Child, Preschool
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Cholinesterases / blood
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Cystic Fibrosis / blood
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Cystic Fibrosis / enzymology
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Cystic Fibrosis / physiopathology*
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Female
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Humans
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Immunoglobulin A
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Immunoglobulin G
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Immunoglobulin M
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Infant
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Leucyl Aminopeptidase / blood
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Liver / physiopathology*
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Liver Cirrhosis / blood
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Liver Cirrhosis / enzymology
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Liver Function Tests*
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Male
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Ornithine Carbamoyltransferase / blood
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Prothrombin / metabolism
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Serum Albumin / metabolism
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Transferrin / metabolism
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Vitamin B 12 / blood
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gamma-Glutamyltransferase / blood
Substances
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Immunoglobulin A
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Immunoglobulin G
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Immunoglobulin M
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Serum Albumin
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Transferrin
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Prothrombin
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Ornithine Carbamoyltransferase
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gamma-Glutamyltransferase
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Alanine Transaminase
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Cholinesterases
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Alkaline Phosphatase
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Leucyl Aminopeptidase
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Vitamin B 12