Additional data on hepatic function tests in cystic fibrosis

Acta Paediatr Scand. 1975 Mar;64(2):337-44. doi: 10.1111/j.1651-2227.1975.tb03844.x.

Abstract

Fifty cystic fibrosis (CF) patients, of whom 9 had multilobular cirrhosis, were observed regularly for a period of 3 years and various liver function tests, indicating cytolysis, cholestasis and cellular insufficiency were performed. Immunoglobulin and prothrombin were assayed. In 9 patients with cirrhosis, the tests were generally abnormal. Two distinct biochemical patterns of cirrhosis were distinguished, one clearly cholestatic and the other of a more cellular type. The distinction was made on the basis of the IgA : Transferrin ratio and of gamma-glutamyl-transpeptidase levels. In the non-cirrhotic patients, a temporary increase of cytolysis and cholestasis was observed in 50% of the cases.

MeSH terms

  • Adolescent
  • Adult
  • Alanine Transaminase / blood
  • Alkaline Phosphatase / blood
  • Child
  • Child, Preschool
  • Cholinesterases / blood
  • Cystic Fibrosis / blood
  • Cystic Fibrosis / enzymology
  • Cystic Fibrosis / physiopathology*
  • Female
  • Humans
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Infant
  • Leucyl Aminopeptidase / blood
  • Liver / physiopathology*
  • Liver Cirrhosis / blood
  • Liver Cirrhosis / enzymology
  • Liver Function Tests*
  • Male
  • Ornithine Carbamoyltransferase / blood
  • Prothrombin / metabolism
  • Serum Albumin / metabolism
  • Transferrin / metabolism
  • Vitamin B 12 / blood
  • gamma-Glutamyltransferase / blood

Substances

  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Serum Albumin
  • Transferrin
  • Prothrombin
  • Ornithine Carbamoyltransferase
  • gamma-Glutamyltransferase
  • Alanine Transaminase
  • Cholinesterases
  • Alkaline Phosphatase
  • Leucyl Aminopeptidase
  • Vitamin B 12