A second hit for TMA

Blood. 2012 Aug 9;120(6):1152-4. doi: 10.1182/blood-2012-06-433235.

Abstract

In this issue of Blood, Fuchs and colleagues provide evidence that circulating DNA and histones, presumably released from neutrophils, would be the second hit for development of thrombotic microangiopathies (TMAs), a group of life-threatening disorders characterized by thrombi in the microvasculature resulting in thrombocytopenia, microangiopathic hemolysis, and organ dysfunction.

Publication types

  • Comment

MeSH terms

  • DNA / blood*
  • Female
  • Humans
  • Male
  • Peroxidase / blood*
  • Thrombotic Microangiopathies / blood*
  • Thrombotic Microangiopathies / diagnosis*

Substances

  • DNA
  • Peroxidase