DNA methylation in cognition comes of age

Susan C Su; Li-Huei Tsai

doi:10.1038/nn.3169

DNA methylation in cognition comes of age

Nat Neurosci. 2012 Jul 26;15(8):1061-2. doi: 10.1038/nn.3169.

Authors

Susan C Su¹, Li-Huei Tsai

Affiliation

¹ Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, Massachusetts, USA.

PMID: 22837034
DOI: 10.1038/nn.3169

Abstract

A study reveals that aged mice have decreased hippocampal expression of the DNA methyltransferase Dnmt3a2; re-expression in aged mice reverses memory deficits, and knockdown in young mice impairs memory formation.

MeSH terms

Aging / genetics
Aging / metabolism*
Aging / psychology
Animals
Cognition Disorders / enzymology*
Cognition Disorders / physiopathology
DNA (Cytosine-5-)-Methyltransferases / antagonists & inhibitors
DNA (Cytosine-5-)-Methyltransferases / biosynthesis
DNA (Cytosine-5-)-Methyltransferases / metabolism*
DNA Methylation / physiology*
DNA Methyltransferase 3A
Hippocampus / enzymology*
Hippocampus / physiopathology
Memory Disorders / enzymology*
Memory Disorders / physiopathology
Mice

Substances

DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A