Abstract
Growth failure is a common and complicated process in children with cystic fibrosis (CF). Growth hormone, which is becoming a more commonly used agent in such patients, has demonstrated beneficial effects aside from increased growth velocity. Recently, insulin-like growth factor-1 has gained significant attention in the understanding of growth failure in children with CF. We report the successful prolonged use of recombinant human insulin-like growth factor-1 in an adolescent boy with CF, who demonstrated significant clinical benefits from the therapy.
Copyright © 2011 Wiley Periodicals, Inc.
MeSH terms
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Adolescent
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Anti-Bacterial Agents / therapeutic use
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Body Height / drug effects
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Body Weight / drug effects
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Cystic Fibrosis / complications
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Cystic Fibrosis / drug therapy*
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Failure to Thrive / complications
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Failure to Thrive / drug therapy*
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Gene Deletion
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Glycated Hemoglobin / analysis
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Humans
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Hypoglycemic Agents / therapeutic use
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Insulin / therapeutic use
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Insulin-Like Growth Factor I / administration & dosage*
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Liver Transplantation
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Lung / drug effects
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Lung / physiopathology
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Male
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Recombinant Proteins / administration & dosage*
Substances
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Anti-Bacterial Agents
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Glycated Hemoglobin A
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Hypoglycemic Agents
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Insulin
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Recombinant Proteins
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hemoglobin A1c protein, human
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Insulin-Like Growth Factor I