Abstract
During an island-wide PCR-based surveillance study of beta-lactam resistance in multidrug-resistant (MDR) Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter calcoaceticus-baumannii complex isolates obtained from 17 different hospitals, 10 KPC-positive Acinetobacter isolates were identified. DNA sequencing of the bla(KPC) gene identified KPC-2, -3, and -4 and a novel variant, KPC-10. This is the first report of a KPC-type beta-lactamase identified in Acinetobacter species.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Acinetobacter / classification*
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Acinetobacter / drug effects*
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Acinetobacter / enzymology
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Acinetobacter / isolation & purification
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Acinetobacter Infections / epidemiology*
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Acinetobacter Infections / microbiology
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Adult
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Aged
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Aged, 80 and over
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Female
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Population Surveillance / methods
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Puerto Rico / epidemiology
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beta-Lactam Resistance / genetics*
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beta-Lactamases / genetics*
Substances
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beta-lactamase KPC-2
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beta-Lactamases