Surveillance of carbapenem-resistant Pseudomonas aeruginosa isolates from Puerto Rican Medical Center Hospitals: dissemination of KPC and IMP-18 beta-lactamases

Antimicrob Agents Chemother. 2009 Apr;53(4):1660-4. doi: 10.1128/AAC.01172-08. Epub 2009 Feb 2.

Abstract

During a 6-month period, 37/513 (7.2%) Pseudomonas aeruginosa isolates belonging to 13 pulsed-field gel electrophoresis (PFGE) groups from Puerto Rican hospitals were carbapenem nonsusceptible. Seven of 37 isolates from four PFGE groups carried bla(IMP-18), and 25/37 isolates from seven PFGE groups carried bla(KPC). The results indicated the clonal spread of bla(KPC)-positive P. aeruginosa isolates into several Puerto Rican hospitals and the dissemination of bla(IMP-18) and bla(KPC) into genetically unrelated isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Outer Membrane Proteins / physiology
  • Carbapenems / pharmacology*
  • Child
  • Child, Preschool
  • Drug Resistance, Bacterial
  • Electrophoresis, Gel, Pulsed-Field
  • Female
  • Humans
  • Infant
  • Male
  • Membrane Transport Proteins / physiology
  • Microbial Sensitivity Tests
  • Middle Aged
  • Polymerase Chain Reaction
  • Porins / physiology
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / enzymology
  • Pseudomonas aeruginosa / genetics
  • beta-Lactamases / genetics
  • beta-Lactamases / physiology*

Substances

  • Bacterial Outer Membrane Proteins
  • Carbapenems
  • Membrane Transport Proteins
  • MexA protein, Pseudomonas aeruginosa
  • Porins
  • OprD protein, Pseudomonas aeruginosa
  • beta-lactamase KPC-1
  • beta-Lactamases
  • beta-lactamase IMP-18, Pseudomonas aeruginosa