Early inflammation in the airways of a cystic fibrosis foetus

J Cyst Fibros. 2007 Jul;6(4):304-8. doi: 10.1016/j.jcf.2006.12.001. Epub 2007 Jan 12.

Abstract

In cystic fibrosis patients, inflammation is often considered to be secondary to chronic infections. In the present study, we show increased levels of pro-inflammatory proteins in the lungs of a cystic fibrosis foetus compared to the lungs of two normal foetuses. Our findings suggest therefore the existence of an early intrinsic pro-inflammatory state in cystic fibrosis airways.

MeSH terms

  • Biomarkers / metabolism
  • Bronchitis / embryology*
  • Bronchitis / metabolism
  • Bronchitis / pathology
  • Cystic Fibrosis / embryology*
  • Cystic Fibrosis / metabolism
  • Cystic Fibrosis / pathology
  • Cytokines / metabolism*
  • Female
  • Fetal Diseases / metabolism*
  • Fetal Diseases / pathology
  • Fluorescent Antibody Technique
  • Gestational Age
  • Humans
  • Immunohistochemistry
  • Lung / metabolism
  • Lung / pathology
  • Microscopy, Confocal
  • NF-kappa B / metabolism*
  • Pregnancy
  • Pregnancy Outcome

Substances

  • Biomarkers
  • Cytokines
  • NF-kappa B