Clonal strains of Pseudomonas aeruginosa in paediatric and adult cystic fibrosis units

Eur Respir J. 2004 Jul;24(1):101-6. doi: 10.1183/09031936.04.00122903.

Abstract

Despite recent reports of clonal strains of Pseudomonas aeruginosa in cystic fibrosis (CF) units, the need for routine microbiological surveillance remains contentious. Sputum was collected prospectively from productive patients attending the regional paediatric and adult CF units in Brisbane, Australia. All P. aeruginosa isolates were typed using pulsed-field gel electrophoresis. Spirometry, anthropometrics, hospitalisations and antibiotic sensitivity data were recorded. The first 100 sputum samples (first 50 patients at each clinic) harboured 163 isolates of P. aeruginosa. A total of 39 patients shared a common strain (pulsotype 2), 20 patients shared a strain with at least one other patient and 41 patients harboured unique strains. Eight patients shared a strain identical to a previously reported Australian transmissible strain (pulsotype 1). Compared with the unique strain group, patients harbouring pulsotype 2 were younger and had poorer lung function. Treatment requirements were similar in these two groups, as were the rates of multiresistance. In conclusion, 59% of patients harboured a clonal strain, supporting the need for routine microbiological surveillance. In contrast to previously described clonal strains, the dominant pulsotype was indistinguishable from nonclonal strains with respect to both colonial morphology and multiresistance. The clinical significance of clonal strains remains uncertain and requires longitudinal study.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Anti-Bacterial Agents / pharmacology*
  • Australia / epidemiology
  • Child
  • Confidence Intervals
  • Cross Infection / prevention & control
  • Cystic Fibrosis / diagnosis
  • Cystic Fibrosis / epidemiology*
  • Cystic Fibrosis / microbiology*
  • Drug Resistance, Bacterial
  • Electrophoresis, Gel, Pulsed-Field
  • Female
  • Hospital Units
  • Humans
  • Incidence
  • Male
  • Microbial Sensitivity Tests
  • Probability
  • Prognosis
  • Prospective Studies
  • Pseudomonas Infections / diagnosis*
  • Pseudomonas Infections / epidemiology*
  • Pseudomonas aeruginosa / classification*
  • Pseudomonas aeruginosa / drug effects
  • Risk Assessment
  • Sex Distribution
  • Sputum / microbiology
  • Statistics, Nonparametric

Substances

  • Anti-Bacterial Agents