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Distinct and Convergent Beneficial Effects of Estrogen and Insulin on Cognitive Function in Healthy Young Men.
Krug R, Beier L, Lämmerhofer M, Hallschmid M. Krug R, et al. Among authors: hallschmid m. J Clin Endocrinol Metab. 2022 Jan 18;107(2):e582-e593. doi: 10.1210/clinem/dgab689. J Clin Endocrinol Metab. 2022. PMID: 34534317 Free PMC article. Clinical Trial.
OBJECTIVE: We investigated the acute effect of estradiol and insulin and of their combined administration on divergent (creative) and convergent (arithmetical) thinking as well as short-term and working verbal memory in healthy young men. METHODS: According to a 2 2 design …
OBJECTIVE: We investigated the acute effect of estradiol and insulin and of their combined administration on divergent (creative) and conver …
Body composition in term offspring after maternal gestational diabetes does not predict postnatal hypoglycemia.
Wiechers C, Balles LS, Kirchhof S, Weber R, Avellina V, Pauluschke-Fröhlich J, Hallschmid M, Fritsche L, Preißl H, Fritsche A, Poets CF, Franz AR. Wiechers C, et al. Among authors: hallschmid m. BMC Pediatr. 2021 Mar 6;21(1):111. doi: 10.1186/s12887-021-02578-3. BMC Pediatr. 2021. PMID: 33676430 Free PMC article.
BACKGROUND: Offspring of mothers with gestational diabetes mellitus (GDM) have an increased risk of neonatal complications like birth trauma due to macrosomia or postnatal hypoglycemia, as well as long-term metabolic sequelae. ...METHODS: This prospective, observati …
BACKGROUND: Offspring of mothers with gestational diabetes mellitus (GDM) have an increased risk of neonatal complications like birth …
Intranasal insulin.
Hallschmid M. Hallschmid M. J Neuroendocrinol. 2021 Apr;33(4):e12934. doi: 10.1111/jne.12934. Epub 2021 Jan 28. J Neuroendocrinol. 2021. PMID: 33506526 Review.
"Brain insulin resistance" is an evolving concept that posits impairments in central nervous insulin signalling as a pathophysiological factor in metabolic and cognitive disorders such as obesity, type 2 diabetes and Alzheimer's disease, and, notably, a target of interventions th …
"Brain insulin resistance" is an evolving concept that posits impairments in central nervous insulin signalling as a pathophysiological fact …
Short-term high-fat feeding induces a reversible net decrease in synaptic AMPA receptors in the hypothalamus.
Liu J, Dimitrov S, Sawangjit A, Born J, Ehrlich I, Hallschmid M. Liu J, et al. Among authors: hallschmid m. J Nutr Biochem. 2021 Jan;87:108516. doi: 10.1016/j.jnutbio.2020.108516. Epub 2020 Oct 3. J Nutr Biochem. 2021. PMID: 33022406 Free article.
Results indicate a reversible down-regulation of hypothalamic glutamatergic synaptic strength in response to short-term high-fat feeding. Preceding the manifestation of obesity, this rapid change in glutamatergic neurotransmission may underlie counter-regulatory efforts to …
Results indicate a reversible down-regulation of hypothalamic glutamatergic synaptic strength in response to short-term high-fat feed …
Neonatal body composition: crossectional study in healthy term singletons in Germany.
Wiechers C, Kirchhof S, Balles L, Avelina V, Weber R, Maas C, Pauluschke-Fröhlich J, Hallschmid M, Preißl H, Fritsche A, Poets CF, Franz AR. Wiechers C, et al. Among authors: hallschmid m. BMC Pediatr. 2019 Dec 12;19(1):488. doi: 10.1186/s12887-019-1837-4. BMC Pediatr. 2019. PMID: 31830928 Free PMC article.
This prospective cross-sectional observational study included 271 healthy, full-term, singletons born between June 2014 and July 2015. Body composition was measured within 96 h of birth using air displacement plethysmography. ...Infant body composition at birth …
This prospective cross-sectional observational study included 271 healthy, full-term, singletons born between June 2014 and July 2015 …
Outcomes and clinical implications of intranasal insulin administration to the central nervous system.
Santiago JCP, Hallschmid M. Santiago JCP, et al. Among authors: hallschmid m. Exp Neurol. 2019 Jul;317:180-190. doi: 10.1016/j.expneurol.2019.03.007. Epub 2019 Mar 15. Exp Neurol. 2019. PMID: 30885653 Review.
It is routinely used in experimental settings to investigate the impact on eating behavior, peripheral metabolism, memory function and brain activation of acute or long-term enhancements in central nervous system insulin signaling. Epidemiological and experimental evidence …
It is routinely used in experimental settings to investigate the impact on eating behavior, peripheral metabolism, memory function and brain …
Metabolic and Cognitive Outcomes of Subchronic Once-Daily Intranasal Insulin Administration in Healthy Men.
Ritze Y, Kern W, Ebner EM, Jahn S, Benedict C, Hallschmid M. Ritze Y, et al. Among authors: hallschmid m. Front Endocrinol (Lausanne). 2018 Nov 13;9:663. doi: 10.3389/fendo.2018.00663. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 30524368 Free PMC article.
Delayed recall of words showed slight improvements by insulin administration in the evening, and serum cortisol concentrations were reduced after 2 weeks of insulin administration in the morning compared to the other groups. Results indicate that catabolic long-term effect …
Delayed recall of words showed slight improvements by insulin administration in the evening, and serum cortisol concentrations were reduced …
Safety of intranasal human insulin: A review.
Schmid V, Kullmann S, Gfrörer W, Hund V, Hallschmid M, Lipp HP, Häring HU, Preissl H, Fritsche A, Heni M. Schmid V, et al. Among authors: hallschmid m. Diabetes Obes Metab. 2018 Jul;20(7):1563-1577. doi: 10.1111/dom.13279. Epub 2018 Apr 6. Diabetes Obes Metab. 2018. PMID: 29508509
CONCLUSIONS: Our retrospective review of published studies on intranasal insulin did not reveal any safety concerns; however, there were insufficient data to ensure the long-term safety of this method of chronic insulin administration. Improved insulin preparations that ca …
CONCLUSIONS: Our retrospective review of published studies on intranasal insulin did not reveal any safety concerns; however, there were ins …
Glycemic increase induced by intravenous glucose infusion fails to affect hunger, appetite, or satiety following breakfast in healthy men.
Schultes B, Panknin AK, Hallschmid M, Jauch-Chara K, Wilms B, de Courbière F, Lehnert H, Schmid SM. Schultes B, et al. Among authors: hallschmid m. Appetite. 2016 Oct 1;105:562-6. doi: 10.1016/j.appet.2016.06.032. Epub 2016 Jun 26. Appetite. 2016. PMID: 27356203
These findings clearly speak against the notion that fluctuations in glycemia and also insulinemia represent major signals in the short-term regulation of hunger and satiety....
These findings clearly speak against the notion that fluctuations in glycemia and also insulinemia represent major signals in the short-t …
[On the detrimental metabolic impact of short, disturbed and erratic sleep].
Hallschmid M, Oster H, Schultes B, Schmid SM. Hallschmid M, et al. Dtsch Med Wochenschr. 2015 Aug;140(17):1278-83. doi: 10.1055/s-0041-103414. Epub 2015 Aug 25. Dtsch Med Wochenschr. 2015. PMID: 26306016 German.
A large number of epidemiological studies indicate that in parallel, the prevalence of the metabolic syndrome and its key components, obesity and type 2 diabetes mellitus, is on the rise. Short-term interventional experiments point to a causal relationship between sleep du …
A large number of epidemiological studies indicate that in parallel, the prevalence of the metabolic syndrome and its key components, obesit …
27 results